Multilevel research strategies characterize contemporary molecular inquiry into biological systems. We outline conceptual, methodological, and explanatory dimensions of these multilevel strategies in microbial ecology, systems biology, protein research, and developmental biology. This review of emerging lines of inquiry in these fields suggests that multilevel research in molecular life sciences has significant implications for philosophical understandings of explanation, modeling, and representation.

The Global Workspace Theory and Information Integration Theory are two of the most currently accepted consciousness models; however, these models do not address many aspects of conscious experience. We compare these models to our previously proposed consciousness model in which the thalamus fills-in processed sensory information from corticothalamic feedback loops within a proposed 3D default space, resulting in the recreation of the internal and external worlds within the mind. This 3D default space is composed of all cells of the body, (...) which communicate via gap junctions and electrical potentials to create this unified space. We use 3D llustrations to explain how both visual and non-visual sensory information may be filled-in within this dynamic space, creating a unified seamless conscious experience. This neural sensory memory space is likely generated by baseline neural oscillatory activity from the default mode network, other salient networks, brainstem, and reticular activating system. (shrink)

Immanuel Kant was a German philosopher. He is a central figure of modern philosophy, and set the terms by which all subsequent thinkers have had to grapple. He argued that human perception structures natural laws, and that reason is the source of morality. His thought continues to hold a major influence in contemporary thought, especially in fields such as metaphysics, epistemology, ethics, political philosophy, and aesthetics.

Intercellular signaling plays an important role in spatially regulated developmental processes. Myxococcus xanthus C signal transmission during fruiting body formation requires motile, densely packed, well aligned cells. tThe fruiting body consists of two domains: an outer domain which has densely packed, well aligned, motile cells: and an inner domain of more loosely packed, non‐motile, sporulating cells. The two domains are characterized by different patterns of C‐dependent gene expression, which begins in the outer domain where C‐signaling is most efficient, and reaches (...) its maximum in the inner domain. These domains may be maintained by a dynamic mechanism which relies on passive transport of the sporulating cells from the outer domain, where sporulation is initiated, to the inner domain by the motile cells in the outer domain. (shrink)

One of the most compelling questions still unanswered in neuroscience is how consciousness arises. In this article, we examine visual processing, the parietal lobe, and contralateral neglect syndrome as a window into consciousness and how the brain functions as the mind and we introduce a mechanism for the processing of visual information and its role in consciousness. We propose that consciousness arises from integration of information from throughout the body and brain by the thalamus and that the thalamus reimages visual (...) and other sensory information from throughout the cortex in a default three-dimensional space in the mind. We further suggest that the thalamus generates a dynamic default three-dimensional space by integrating processed information from corticothalamic feedback loops, creating an infrastructure that may form the basis of our consciousness. Further experimental evidence is needed to examine and support this hypothesis, the role of the thalamus, and to further elucidate the mechanism of consciousness. (shrink)

The complex activity of the human brain makes it difficult to get a big picture of how the brain works and functions as the mind. We examine pertinent studies, as well as evolutionary and embryologic evidence to support our theoretical model consisting of separate but interactive layers of human neural activity. The most basic layer involves default mode network (DMN)activity and cardiorespiratory oscillations. We propose that these oscillations support other neural activity and cognitive processes. The second layer involves limbic system (...) activity accompanied by corresponding changes in cardiorespiratory oscillations. The third layer consists of corticothalamic processing and involves higher cortical functions including awareness, cognition,and consciousness. These layers interact to form the complex neural activity of the human brain. Examining the origins and relationships of various neural and physiologic oscillations may provide better understanding of human neurophysiology and consciousness. (shrink)

Defining and identifying causal intervention effects for transmissible infectious disease outcomes is challenging because a treatment – such as a vaccine – given to one individual may affect the infection outcomes of others. Epidemiologists have proposed causal estimands to quantify effects of interventions under contagion using a two-person partnership model. These simple conceptual models have helped researchers develop causal estimands relevant to clinical evaluation of vaccine effects. However, many of these partnership models are formulated under structural assumptions that preclude realistic (...) infectious disease transmission dynamics, limiting their conceptual usefulness in defining and identifying causal treatment effects in empirical intervention trials. In this paper, we propose causal intervention effects in two-person partnerships under arbitrary infectious disease transmission dynamics, and give nonparametric identification results showing how effects can be estimated in empirical trials using time-to-infection or binary outcome data. The key insight is that contagion is a causal phenomenon that induces conditional independencies on infection outcomes that can be exploited for the identification of clinically meaningful causal estimands. These new estimands are compared to existing quantities, and results are illustrated using a realistic simulation of an HIV vaccine trial. (shrink)

This is the third of a series of books by Aschenbrenner dealing with the nature of appraisive concepts, following The Concept of Value and The Concepts of Criticism. In the previous works he attempted to identify, classify and provide a general theoretical framework for all appraisive or value concepts. The first part of the present book expands that analysis by investigating the emergence of appraisive concepts and exploring in depth the nature of the classifications made in the previous books. Aschenbrenner (...) begins with elemental sense experience and works his way to complex human interactions, where he finds that expectations of others lead to demands, and that their fulfillment or nonfulfillment leads to the use of appraisive characterization, ranging from the expression of emotions to the articulation of rights and duties. He provides details of the verbal and conceptual means by which credit and discredit are expressed, modes of opposition between concepts, and various dimensions of meaning. On a more general level, his view is that assertions using appraisive terms are not true or false, nor in need of verification; rather they are evaluated as apt or unapt and as fair or unfair, just or unjust. But these evaluations are themselves appraisive discourse, only at another level. (shrink)

In Making it Explicit Robert Brandom claims that perspectivally hybrid de re attitude ascriptions explain what an agent actually did, from the point of view of the ascriber, whether or not that was what the agent intended to do. There is a well-known problem, however, first brought to attention by Quine, but curiously ignored by Brandom, that threatens to undermine the role of de re ascriptions in the explanation of action, a problem that stems directly from the fact that, unlike (...) de dicto ascriptions, they permit the attribution of inconsistent attitudes to agents. I propose a solution to the problem which I believe is consistent with Brandom’s approach to the nature of intentionality and the explanation of action. (shrink)

I interpret and defend Sellars’ intemalist view of perceptual justification which argues that perceivers have evidence for their perceptual beliefs that includes a higher-order belief about the circumstances in which those beliefs arise, and an epistemic belief about the reliability of beliefs that are formed in those circumstances. The pattem of inference that occurs in ordinary cases of perception is elicited.I then defend this account of perceptual evidence against 1) AIston’s objection that ordinary perceivers are not as critical and reflective (...) as this view requires them to be; and 2) the charge that intemalism leads to various forms of infinite regress and circular reasoning. It is granted that subjects must have further grounds for their justifying reasons, and an attempt is made to identify these second-order reasons. In particular, I argue that epistemic beliefs are grounded in the perceiver’s awareness that his present experience-cum-conditions fits into a larger pattem of similar past experiences that were reliably connected with their objects. (shrink)

This book explores for the first time an idea common to both Plato and Aristotle: although people are separate, their lives need not be; one person's life may overflow into another's, so that helping someone else is a way of serving oneself. Price considers how this idea unites the philosophers' treatments of love and friendship (which are otherwise very different), and demonstrates that this view of love and friendship, applied not only to personal relationships, but also to the household and (...) even the city-state, promises to resolve the old dichotomy between egoism and altruism. (shrink)

It is a long time since I have admired a book as much as I admire this one. It is a long time since I have disagreed with a book as profoundly as I disagree with this one. I hope this combination of reactions on my part has more than whatever limited biographical interest it has. I hope it helps to signal the combination of excellence and provocation that mark Timothy Williamson's book, which is at once beautifully clear, forcefully argued, (...) continually insightful, and, in my view, deeply wrong.One thing that I admire about the book is Williamson's preparedness to reflect philosophically on the nature of philosophy, something that is surprisingly rare in a discipline that is marked by such a high degree of self-consciousness and in which there are so few scruples about reflecting on the nature of other disciplines. One thing that gives me pause is Williamson's lack of serious engagement with the history of philosophy. 1 I am convinced that the philosophy of philosophy will always be seriously handicapped if it is as dissociated from the history of philosophy as this. But I shall not dwell on that concern here, because Williamson is clear enough about where his interests lie and I would be in danger, if I did, of succumbing to that familiar absurdity of berating an author for not having written a numerically different book.What I will say is that Williamson's failure to engage seriously with the history of philosophy seems to me indicative of a scientism about philosophy which, despite how much he does to motivate his conception of the discipline, is manifest in how much …. (shrink)

This chapter contains section titled: Introduction1 Was the Early Wittgenstein a Transcendental Idealist? Was the Later Wittgenstein a Transcendental Idealist?

"A consistently clear, comprehensive and accessible introduction which carefully sifts Foucault's work for both its strengths and weaknesses. McHoul and Grace show an intimate familiarity with Foucault's writings and a lively, but critical engagement with the relevance of his work. A model primer." -Tony Bennett, author of Outside Literature In such seminal works as Madness and Civilization, Discipline and Punish , and The History of Sexuality , the late philosopher Michel Foucault explored what our politics, our sexuality, our societal conventions, (...) and our changing notions of truth told us about ourselves. In the process, Foucault garnered a reputation as one of the pre-eminent philosophers of the latter half of the twentieth century and has served as a primary influence on successive generations of philosophers and cultural critics. With A Foucault Primer , Alec McHoul and Wendy Grace bring Foucault's work into focus for the uninitiated. Written in crisp and concise prose, A Foucault Primer explicates three central concepts of Foucauldian theory-discourse, power, and the subject-and suggests that Foucault's work has much yet to contribute to contemporary debate. (shrink)

Rudolf Carnap is widely regarded as one of the most important philosophers of the twentieth century. Born in Germany and later a US citizen, he was a founder of the philosophical movement known as Logical Empiricism. He was strongly influenced by a number of different philosophical traditions, and also by the German Youth Movement, the First World War, and radical socialism. This book places his central ideas in a broad cultural, political and intellectual context, showing how he synthesised many different (...) currents of thought to achieve a philosophical perspective that remains strikingly relevant in the twenty-first century. Its rich account of a philosopher's response to his times will appeal to all who are interested in the development of philosophy in the twentieth century. (shrink)

DISCOURSE; EXPRESSION (i) 'Discourse' is a word with a variety of meanings. One of the more useful is as an omnibus word covering both thought and talk. ...

For over two thousand years thought about the infinite was dominated by Aristotelian hostility to the idea that the infinite could be a legitimate object of mathematical study. Then Cantor's work late in the nineteenth century seemed to overturn this orthodoxy. However, by highlighting ways in which infinitude still could not be brought under the control of mathematicians, Cantor's work may in fact have reinforced the orthodoxy.

Lifestyle diseases constitute an increasing proportion of health problems and this trend is likely to continue. A better understanding of the responsibility argument is important for the assessment of policies aimed at meeting this challenge. Holding individuals accountable for their choices in the context of health care is, however, controversial. There are powerful arguments both for and against such policies. In this article the main arguments for and the traditional arguments against the use of individual responsibility as a criterion for (...) the distribution of scarce health resources will be briefly outlined. It is argued that one of the most prominent contemporary normative traditions, liberal egalitarianism, presents a way of holding individuals accountable for their choices that avoids most of the problems pointed out by the critics. The aim of the article is to propose a plausible interpretation of liberal egalitarianism with respect to responsibility and health care and assess it against reasonable counter-arguments. (shrink)

A. W. Price explores the varying ways in which context is relevant to our reasoning about what to do.

This essay constitutes an attempt to probe the very idea of a saying/showing distinction of the kind that Wittgenstein advances in the Tractatus—to say what such a distinction consists in, to say what philosophical work it has to do, and to say how we might be justified in drawing such a distinction. Towards the end of the essay the discussion is related to Wittgenstein’s later work. It is argued that we can profitably see this work in such a way that (...) a saying/showing distinction arises there too. In particular, in the final sub-section of the essay, it is suggested that we can see in Wittgenstein’s later work an inducement to say what we are shown. (shrink)

As earthquakes expose geological faults, so mental conflict reveals tendencies to rupture within the mind. Dissension is rife not only between people but also within them, for each of us is subject to a contrariety of desires, beliefs, motivations, aspirations. What image are we to form of ourselves that might best enable us to accept the reality of discord, or achieve the ideal of harmony? Greek philosophers offer us a variety of pictures and structures intended to capture the actual and (...) the possible either within a reason that fails to be resolute, or within a split soul that houses a play of forces. Reflection upon them alerts us to the elusiveness at once of mental reality, and of the understanding by which we hope to capture and transform it. Studying in turn the treatments of _Mental Conflict_ in Socrates, Plato, Aristotle and the Stoics, A.W. Price demonstrates how the arguments of the Greeks are still relevant to philosophical discussion today. (shrink)

Titian's Rape of Europa is highly praised for its luminous colors and sensual textures. But the painting has an overlooked dark side, namely that it eroticizes rape. I argue that this is an ethical defect that diminishes the painting aesthetically. This argument-that an artwork can be worse off qua work of art precisely because it is somehow ethically problematic-demonstrates that feminist concerns about art can play a legitimate role in art criticism and aesthetic appreciation.

A.W. Price explores the views of Plato and Aristotle on how virtue of character and practical reasoning enable agents to achieve eudaimonia--the state of living or acting well. He provides a full philosophical analysis and argues that the perennial question of action within human life is central to the reflections of these ancient philosophers.

There is a current debate about the grammar of intention: do I intend to φ, or that I φ? The equivalent question in Aristotle relates especially to choice. I argue that, in the context of practical reasoning, choice, as also wish, has as its object an act. I then explore the role that this plays within his account of the relation of thought to action. In particular, I discuss the relation of deliberation to the practical syllogism, and the thesis that (...) the conclusion of the second is an action. (shrink)

How, in pursuit of ontological neutrality, should one talk about values? I propose to say: there are values. Those three words do nothing to define within what kind of conception of a world values are at home.1 I take it that the ‘realist’ must have more to say about values and their world. I recognize that an ‘anti-realist’ may prefer to talk of value-terms ; I ask him to wait and see whether taking the linguistic turn is the only way (...) to put values in their place. (shrink)

As earthquakes expose geological faults, so mental conflict reveals tendencies to rupture within the mind. Dissension is rife not only between people but also within them, for each of us is subject to a contrariety of desires, beliefs, motivations, aspirations. What image are we to form of ourselves that might best enable us to accept the reality of discord, or achieve the ideal of harmony? Greek philosophers offer us a variety of pictures and structures intended to capture the actual and (...) the possible either within a reason that fails to be resolute, or within a split soul that houses a play of forces. Reflection upon them alerts us to the elusiveness at once of mental reality, and of the understanding by which we hope to capture and transform it. Studying in turn the treatments of _Mental Conflict_ in Socrates, Plato, Aristotle and the Stoics, A.W. Price demonstrates how the arguments of the Greeks are still relevant to philosophical discussion today. (shrink)

(1978). Democratic Values and the Managerial Prerogative: a case study of headteachers and democratised school boards. Educational Studies: Vol. 4, No. 1, pp. 29-44.

This historical study of early 19th-century opposition to vivisection suggests that the moral persona of the vivisector was an important theme. Vivisectors claimed they deliberately suppressed their feelings to perform scientifically necessary experiments: Where there was reason, there could be no cruelty. Their critics argued they were callous and indifferent to suffering, which was problematic for medical practitioners, who were expected to be merciful and compassionate. This anthropocentric debate can be located within the virtue ethics tradition: Compassion for animals signified (...) a humane character. The 1876 Vivisection Act facilitated experimentation by separating the practice of vivisection from that of medicine. (shrink)